| Details |
| Disease Name | Glioma |
| Nocoding RNA Name | lincRNA-ROR |
| Expression Pattern | down-regulated |
| Species | Homo sapiens |
| Detection Methods | Real-time Quantitative PCR,Flow Cytometry etc. |
| Target | N/A |
| Tissue | brain(brain tumor tissue) |
| Treatment | N/A |
| PubMed ID | 25651893 |
| Year | 2015 |
| Detail Description | lincRNA-ROR expression was significantly lower in glioma tissues than in adjacent normal tissues. Knockdown of lincRNA-ROR expression by small hairpin RNA (shRNA) significantly elevated the cell proliferation and enhanced the CD133 expression rate and glioma stem sphere-forming ability in U87 cells, while overexpression of lincRNA-ROR in U87 cells showed the opposite effect. Moreover, we found that the expression of lincRNA-ROR was negatively correlated with stem cell factor KLF4 and the up- and down-regulation of lincRNA-ROR resulted in inverse modulation of KLF4 messenger RNA (mRNA) expression. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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