| Disease Name |
Alzheimer Disease |
| Nocoding RNA Name |
mmu-miR-16 |
| Expression Pattern |
up-regulated |
| Species |
Mus musculus |
| Detection Methods |
SemiQuantitative RT-PCR,Real-time RT-PCR,Western Blot,Luciferase Reporter Assay etc. |
| Target |
APP |
| Tissue |
brain |
| Treatment |
N/A
|
| PubMed ID |
20619502 |
| Year |
2012 |
| Detail Description |
Overexpression of miR-16,both in vitro and in vivo,led to reduced APP protein expression.Taken together,these findings demonstrate that APP is a target of miR-16 and the abnormally low expression of miR-16 could potentially lead to APP protein accumulation in AD mice. |
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