| Details |
| Disease Name | Alzheimer Disease |
| Nocoding RNA Name | mmu-miR-186 |
| Expression Pattern | down-regulated |
| Species | Mus musculus |
| Detection Methods | qRT-PCR,Luciferase Reporter Assay,Western Blot,transfection etc. |
| Target | BACE1 |
| Tissue | cortex |
| Treatment | N/A |
| PubMed ID | 26710318 |
| Year | 2016 |
| Detail Description | In conclusion, we found that miR-186 gradually decreases in the mouse brain cortex during aging.MiR-186 is a potent negative regulator of BACE1 expression in neuronal cells. Both miR-186 and BACE1 are expressed in the brain and are particularly enriched in neurons.Overexpression of miR-186 markedly decreased Aβ level.Down-regulation of miR-186 by the aging process may be involved in the induction of BACE1 expression and thereby cause the accumulation of Aβ during aging. |
NSDNA: The Nervous System Disease NcRNAome Atlas
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