Cancer name Non Small Cell Lung Cancer
Cancer Type NSCLC
Immunotherapy type Immune Checkpoint Therapy
Treatment Nivolumab
Drugstatus Approved
Drugbank ID DB09035(DB06132)
Checkpoints PD-1
Signature Type Protein
Signature PD-L1
Official Symbol CD274
Mode of action PROT_R_UP
Description for ‘mode of action’：the ‘mode of action’ for signature is composed of three parts: A_B_C. A describes the level at which the corresponding signature changes, it may contain the following values: TRAN(translation), PROT(protein), CE(cell), METH(methylation), AC(acetylation), PHOS(phosphorylation), MU(mutation), SNP(single nucleotide polymorphism), GLYC(glycosylation) and PATH(pathway). B describes the corresponding signature in which cancer immunotherapy condition group has changed, it may contain the following values: R (immunotherapy response group), NR(immunotherapy non-response group), D (Immunotherapy group), ND (No immunotherapy group). C describes the change detail (specific direction) of the corresponding signature, it may contain the following values: UP (High gene/protein expression or increased cellular abundance or enhanced epigenetic modification), DN (Low gene/protein expression or reduced cellular abundance or attenuated epigenetic modifications), LOSS (deletion mutation), GAIN (gain mutation)，Other. For example, the search/browse detail result for CD274 was “PROT_R_UP”, it can be interpreted that the protein level of CD274 was upregulated in immunotherapy response individuals.
Experimental clinical trial phase 3
Description Nivolumab was associated with a longer progression-free survival (PFS) and OS and higher objective response rates (ORRs) than docetaxel in the patients whose tumors exhibited PD-L1 expression levels of>1%,>5%, and>10%, but not in patients with PD-L1 expression in<1% of tumor cells, indicating that PD-L1 expression is richer in responders than innonresponders
PMID 29153898
Title The Significance of the PD-L2 Expression in Non-Small-Cell Lung Cancer: Trenchant Double Swords as Predictive and Prognostic Markers