• Pan-cancer associated ceRNA database (Pan-ceRNADB) is offered to the public as a freely available resource to investigate mRNA related ceRNA-ceRNA landscape and significance across 20 major cancer types. Cross-talk between competitive endogenous RNAs (ceRNAs) through shared miRNAs represents a novel layer of gene regulation that plays important roles in the physiology and development of cancers. However, a global view of their system-level properties across various types of cancers is still unknown.
• Here, we constructed the mRNA related ceRNA-ceRNA interaction landscape across 20 cancer types by systematically analyzing molecular profiles of 5,203 tumours and miRNA regulations. Systematic construction and analysis of mRNA-related ceRNA regulatory network across multiple cancers, can help to elucidate the commonalities and differences in mechanisms of cancers.
• Pan-ceRNADB offers the search and download the mRNA related ceRNA-ceRNA interactions in specific cancer. Please select "Help" for more details on Pan-ceRNADB.
• For a better display and full functionality of our database, please use Google Chrome or Opera.