Spatial drug perturbation map

SDMap： a database for Spatial Drug perturbation Map

SDMap collected large-scale spatial transcriptomics (ST) and drug perturbation data, and establish the association between drug perturbation and cells/spots within spatial tissues. Currently, SDMap contains:

• 5,490,079 spatial locations (spots/cells) from 989 slices of human
• 538,419 instances (i.e. 538,419 drug-concentration-time combination) for 33,149 drugs under varying concentrations, treatment durations and dosages
• associations among 5,490,079 spatial locations and 538,419 treatment instances for the perturbation of 33,149 drugs
• the spatial distribution of drug target activities and its correlation with the perturbation effects of drugs
• the correlation between spatial cell identity and drug perturbation
• the distribution of drug perturbation cells along the spatial trajectory
• the perturbation effects of drug dosage and duration on the spatial microenvironment
• the impact of spatial cellular functional activity on drug perturbation
• spatial perturbation effect map of drug combination
• 3D distribution of drug perturbation effects in spatial tissue

SDMap will provide important insights for investigating the influence of spatial heterogeneity on the action of drugs, and serve as a comprehensive database for discovery of spatial-dimensional precision therapy targets and dissecting drug-related mechanisms.